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Article

Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs

26 Jun 2018

Abstract excerpt

Maturity onset diabetes of the young (MODY) is a hereditary form of diabetes mellitus presenting at childhood or adolescence, which eventually leads to pancreatic β-cells dysfunction. The underlying genetic basis of MODY disorders is haploinsufficiency, where loss-of-function mutations in a single allele cause the diabetic phenotype in heterozygous patients. MODY1 is a type of MODY disorder resulting from a...

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PMID: 29990710
DOI: 10.1016/j.scr.2018.06.013

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