Article
Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.
Breast cancer research : BCR - 1 Jan 2009
Neuhausen Susan L, Brummel Sean, Ding Yuan Chun, Singer Christian F, Pfeiler Georg, Lynch Henry T, Nathanson Katherine L, Rebbeck Timothy R, Garber Judy E, Couch Fergus, Weitzel Jeffrey, Narod Steven A, Ganz Patricia A, Daly Mary B, Godwin Andrew K, Isaacs Claudine, Olopade Olufunmilayo I, Tomlinson Gail, Rubinstein Wendy S, Tung Nadine, Blum Joanne L, Gillen Daniel L
Abstract excerpt
INTRODUCTION: Women who carry mutations in BRCA1 and BRCA2 have a substantially increased risk of developing breast cancer as compared with the general population. However, risk estimates range from 20 to 80%, suggesting the presence of genetic and/or environmental risk modifiers. Based on extensive in vivo and in vitro studies, one important pathway for breast cancer pathogenesis may be the insulin-like growth...
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