Article
Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2011
Neuhausen Susan L, Brummel Sean, Ding Yuan Chun, Steele Linda, Nathanson Katherine L, Domchek Susan, Rebbeck Timothy R, Singer Christian F, Pfeiler Georg, Lynch Henry T, Garber Judy E, Couch Fergus, Weitzel Jeffrey N, Godwin Andrew, Narod Steven A, Ganz Patricia A, Daly Mary B, Isaacs Claudine, Olopade Olufunmilayo I, Tomlinson Gail E, Rubinstein Wendy S, Tung Nadine, Blum Joanne L, Gillen Daniel L
Abstract excerpt
BACKGROUND: BRCA1 and BRCA2 mutation carriers have a lifetime breast cancer risk of 40% to 80%, suggesting the presence of risk modifiers. We previously identified significant associations in genetic variants in the insulin-like growth factor (IGF) signaling pathway. Here, we investigate additional IGF signaling genes as risk modifiers for breast cancer development in BRCA carriers. METHODS: A cohort of 1,019...
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