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Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C.

Cancer science - 1 Apr 2004

Shibahara Kotaro, Uchiumi Takeshi, Fukuda Takao, Kura Shinobu, Tominaga Yohei, Maehara Yoshihiko, Kohno Kimitoshi, Nakabeppu Yusaku, Tsuzuki Teruhisa, Kuwano Michihiko

Abstract excerpt

The eukaryotic Y-box binding protein-1 (YB-1) functions in various biological processes, including transcriptional and translational control, DNA repair, drug resistance, and cell proliferation. To elucidate the physiological role of the YB-1 protein, we disrupted one allele of mouse YB-1 in embryonic stem (ES) cells. Northern blot analysis revealed that YB-1(+/-) ES cells with one intact allele contain...

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Identifiers

PMID: 15072594
DOI: 10.1111/j.1349-7006.2004.tb03214.x
PMCID: PMC11159763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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