Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ICln is essential for cellular and early embryonic viability.

The Journal of biological chemistry - 28 Apr 2000

Pu W T, Wickman K, Clapham D E

Abstract excerpt

pICln is a 26-kDa protein that is ubiquitously expressed and highly conserved from Xenopus laevis to Homo sapiens. The physiological functions of pICln remain to be established. To address this question, we disrupted the ICln gene in embryonic stem cells. We found that murine embryos lacking ICln die early in gestation (between stages E3.5 and E7.5). Furthermore, we found that ICln is essential for embryonic stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Survival
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Gene Targeting

Share to Ion Channels

Share to Recombination, Genetic

Share to Stem Cells

Source

Identifiers

PMID: 10777517
DOI: 10.1074/jbc.275.17.12363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ICln is essential for cellular and early embryonic viability.PMID 10777517Read ↗

Role of <i>Filia</i> , a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesisSemantic proximity Read ↗

NIPBL+/- haploinsufficiency reveals a constellation of transcriptome disruptions in the pluripotent and cardiac states.Semantic proximity Read ↗

Gastrulation-stage gene expression in Nipbl+/- mouse embryos foreshadows the development of syndromic birth defects.Semantic proximity Read ↗

A subcortical maternal complex essential for preimplantation mouse embryogenesis.Semantic proximity Read ↗

The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.Semantic proximity Read ↗

Role of aberrant protein modification, assembly, and localization in cloned embryo phenotypes.Semantic proximity Read ↗

Novel mutations in genes encoding subcortical maternal complex proteins may cause human embryonic developmental arrest.Semantic proximity Read ↗

The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.Semantic proximity Read ↗

The subcortical maternal complex: emerging roles and novel perspectives.Semantic proximity Read ↗

NLRPs, the subcortical maternal complex and genomic imprinting.Semantic proximity Read ↗

Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations.Semantic proximity Read ↗

Mammalian Pabpc4 is non-essential for development, but has roles in growth, post-natal survival and haematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.