Article
RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes.
Advances in cancer research - 1 Jan 2008
Ito Yoshiaki
Abstract excerpt
Mouse embryonal carcinoma (EC) cells, also called teratocarcinoma stem cells, are nonpermissive for polyomavirus growth, whereas differentiated derivatives of the cells are permissive. Mutant viruses capable of growing in EC cells can be isolated. They have genomic alterations within the viral enhancer, which is required for viral gene expression and DNA replication. This viral regulatory region was considered as...
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