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Article

Homozygous disruption of the Tip60 gene causes early embryonic lethality.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2009

Hu Yaofei, Fisher Joseph B, Koprowski Stacy, McAllister Donna, Kim Min-Su, Lough John

Abstract excerpt

Tat-interactive protein 60 (Tip60) is a member of the MYST family, proteins of which are related by an atypical histone acetyltransferase (HAT) domain. Although Tip60 has been implicated in cellular activities including DNA repair, apoptosis, and transcriptional regulation, its function during embryonic development is unknown. We ablated the Tip60 gene (Htatip) from the mouse by replacing exons 1-9 with a...

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Identifiers

PMID: 19842187
DOI: 10.1002/dvdy.22110
PMCID: PMC2801416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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