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Article

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice

10 Jul 2017

Abstract excerpt

Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for hyperacetylation-mediated histone replacement remains poorly understood. Here, we report that EPC1 and TIP60, two critical components of the mammalian nucleosome acetyltransferase of H4 (NuA4)...

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Share to Epigenetics and DNA Methylation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 28694333
DOI: 10.1128/mcb.00082-17

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