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TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

18 Oct 2017

Abstract excerpt

HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor. However, the potential mechanisms endowing its tumor suppressor ability remain incompletely understood. It plays a vital role in virus-induced cancers where TIP60 down-regulates the expression of human papillomavirus (HPV) oncoprotein E6 which in turn destabilizes TIP60. This intrigued us to identify the role of TIP60, in the context of...

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Share to Chromosomal and Genetic Variations
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

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PMID: 29045464
DOI: 10.1371/journal.ppat.1006681

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TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoterPMID 29045464Read ↗

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