Article
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Nature - 30 Aug 2007
Gorrini Chiara, Squatrito Massimo, Luise Chiara, Syed Nelofer, Perna Daniele, Wark Landon, Martinato Francesca, Sardella Domenico, Verrecchia Alessandro, Bennett Samantha, Confalonieri Stefano, Cesaroni Matteo, Marchesi Francesco, Gasco Milena, Scanziani Eugenio, Capra Maria, Mai Sabine, Nuciforo Paolo, Crook Tim, Lough John, Amati Bruno
Abstract excerpt
The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a co-regulator of transcription factors that either promote or suppress tumorigenesis, such as Myc and p53. Second, Tip60 modulates DNA-damage response (DDR) signalling, and a DDR triggered by oncogenes can counteract tumour progression. Using E(mu)-myc transgenic mice that are heterozygous for a Tip60 gene (Htatip)...
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