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Article

The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair

26 Feb 2016

Abstract excerpt

The acetyltransferase Tip60/Kat5 acetylates both histone and non-histone proteins, and is involved in a variety of biological processes. By acetylating p53, Tip60 controls p53-dependent transcriptional activity and so is implicated as a tumor suppressor. However, many breast cancers with low Tip60 also show p53 mutation, implying that Tip60 has a tumor suppressor function independent of its acetylation of p53....

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PMID: 26915295
DOI: 10.1038/cdd.2015.173

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The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repairPMID 26915295Read ↗

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