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Article

Targeting cancer using KAT inhibitors to mimic lethal knockouts.

Biochemical Society transactions - 15 Aug 2016

Brown James A L, Bourke Emer, Eriksson Leif A, Kerin Michael J

Abstract excerpt

Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC), and are exciting targets for drug development. Importantly, dysfunctional acetylation has been implicated in numerous diseases, including cancer. Within the HAT...

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Identifiers

PMID: 27528742
DOI: 10.1042/BST20160081
PMCID: PMC4984449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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