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Article

Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jun 2010

Pi Hyun Jae, Otmakhov Nikolai, Lemelin David, De Koninck Paul, Lisman John

Abstract excerpt

Ca(2+)/calmodulin-dependent kinase II (CaMKII) is a key mediator of long-term potentiation (LTP). Whereas acute intracellular injection of catalytically active CaMKII fragments saturates LTP (Lledo et al., 1995), an autonomously active form (T286D) of CaMKII holoenzyme expressed in transgenic mic...

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Identifiers

PMID: 20592192
DOI: 10.1523/JNEUROSCI.0133-10.2010
PMCID: PMC2903435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20592192-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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