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Article

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation.

Neuron - 10 Apr 2013

Mairet-Coello Georges, Courchet Julien, Pieraut Simon, Courchet Virginie, Maximov Anton, Polleux Franck

Abstract excerpt

Amyloid-β 1-42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) progression. Recent results suggested that Aβ42 oligomers trigger activation of AMP-activated kinase (AMPK), and its activation is inc...

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Identifiers

PMID: 23583109
DOI: 10.1016/j.neuron.2013.02.003
PMCID: PMC3784324

Genes

CAMKK2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23583109-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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