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Article

Characterisation of influenza A viruses with mutations in segment 5 packaging signals.

Vaccine - 23 Oct 2009

Hutchinson Edward C, Wise Helen M, Kudryavtseva Katerine, Curran Martin D, Digard Paul

Abstract excerpt

Influenza A virus vRNA segments contain specific packaging signals at their termini that overlap the coding regions. To further characterise segment 5 packaging signals, we introduced synonymous mutations into the terminal coding regions of the vRNA and characterised the replicative fitness of the resulting viruses. Most mutations tested were well-tolerated, but a virus with alterations to NP codons 464-466, near...

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Identifiers

PMID: 19840659
DOI: 10.1016/j.vaccine.2009.05.053
PMCID: PMC2771075

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Source receipt: pubmed, retrieved 7 Sept 2026.

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