Article

Replication competent, 10-segmented influenza viruses as antiviral therapeutics

2019-02-11

Abstract excerpt

Influenza A viruses (IAVs) encode their genome as eight negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging of a mutated segment, renders the resultant virion incompletely infectious. It is known that the accumulation of these defective particles can limit viral disease by interfering with the spread of fully infectious particles. In order to harness this phe...

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Literature Corpus work: cc59110a-d58b-595d-984a-55bf6c1f1c1a
DOI: 10.1101/547059

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