Article
Codon conservation in the influenza A virus genome defines RNA packaging signals.
Nucleic acids research - 1 Jan 2007
Gog Julia R, Afonso Emmanuel Dos Santos, Dalton Rosa M, Leclercq India, Tiley Laurence, Elton Debra, von Kirchbach Johann C, Naffakh Nadia, Escriou Nicolas, Digard Paul
Abstract excerpt
Genome segmentation facilitates reassortment and rapid evolution of influenza A virus. However, segmentation complicates particle assembly as virions must contain all eight vRNA species to be infectious. Specific packaging signals exist that extend into the coding regions of most if not all segments, but these RNA motifs are poorly defined. We measured codon variability in a large dataset of sequences to identify...
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