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Article

Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus.

Journal of virology - 1 Dec 2008

Hutchinson Edward C, Curran Martin D, Read Eliot K, Gog Julia R, Digard Paul

Abstract excerpt

The genomic viral RNA (vRNA) segments of influenza A virus contain specific packaging signals at their termini that overlap the coding regions. To further characterize cis-acting signals in segment 7, we introduced synonymous mutations into the terminal coding regions. Mutation of codons that are normally highly conserved reduced virus growth in embryonated eggs and MDCK cells between 10- and 1,000-fold compared...

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Identifiers

PMID: 18815307
DOI: 10.1128/JVI.01634-08
PMCID: PMC2583641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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