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Article

Functionality of IAV packaging signals depends on site-specific charges within the viral nucleoprotein.

Journal of virology - 16 Apr 2024

Ciminski Kevin, Flore Viktoria, Jakob Celia, Mues Helen, Smedegaard Frederiksen Anne, Schwemmle Martin, Bolte Hardin, Giese Sebastian

Abstract excerpt

The coordinated packaging of the segmented genome of the influenza A virus (IAV) into virions is an essential step of the viral life cycle. This process is controlled by the interaction of packaging signals present in all eight viral RNA (vRNA) segments and the viral nucleoprotein (NP), which binds vRNA via a positively charged binding groove. However, mechanistic models of how the packaging signals and NP work...

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Identifiers

PMID: 38470155
DOI: 10.1128/jvi.01972-23
PMCID: PMC11019843

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