Article
Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.
PloS one - 19 Oct 2009
Bilodeau Mélanie, MacRae Tara, Gaboury Louis, Laverdure Jean-Philippe, Hardy Marie-Pierre, Mayotte Nadine, Paradis Véronique, Harton Sébastien, Perreault Claude, Sauvageau Guy
Abstract excerpt
The cystatin protein superfamily is characterized by the presence of conserved sequences that display cysteine protease inhibitory activity (e.g., towards cathepsins). Type 1 and 2 cystatins are encoded by 25 genes of which 23 are grouped in 2 clusters localized on mouse chromosomes 16 and 2. The expression and essential roles of most of these genes in mouse development and hematopoiesis remain poorly...
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