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Article

Prdm16 is a physiologic regulator of hematopoietic stem cells.

Blood - 12 May 2011

Aguilo Francesca, Avagyan Serine, Labar Amy, Sevilla Ana, Lee Dung-Fang, Kumar Parameet, Lemischka Ihor R, Zhou Betty Y, Snoeck Hans-Willem

Abstract excerpt

Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute myeloblastic leukemias. As many genes involved in leukemogenic fusions play a role in normal hematopoiesis, we analyzed the role of Prdm16 in the biology of...

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Source

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Identifiers

PMID: 21343612
DOI: 10.1182/blood-2010-08-300145
PMCID: PMC3109532

Genes

PRDM16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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