Article
Alterations in the mir-15a/16-1 Loci Impairs Its Processing and Augments B-1 Expansion in De Novo Mouse Model of Chronic Lymphocytic Leukemia (CLL).
PloS one - 1 Jan 2016
Kasar Siddha, Underbayev Chingiz, Hassan Moinuddin, Ilev Ilko, Degheidy Heba, Bauer Steven, Marti Gerald, Lutz Carol, Raveche Elizabeth, Batish Mona
Abstract excerpt
New Zealand Black (NZB) mice, a de novo model of CLL, share multiple characteristics with CLL patients, including decreased expression of miR-15a/16-1. We previously discovered a point mutation and deletion in the 3' flanking region of mir-16-1 of NZB and a similar mutation has been found in a small number of CLL patients. However, it was unknown whether the mutation is the cause for the reduced miR-15a/16-1...
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