Loss of Bicra/Gltscr1 leads to a defect in fetal liver macrophages responsible for erythrocyte maturation in mice.

Abstract excerpt

GLTSCR1, a protein encoded by the Bicra gene, is a defining subunit of the SWI/SNF (also called mammalian BAF) chromatin remodeling subcomplex called GBAF/ncBAF. To determine the role of GLTSCR1 during mouse development, we generated a Bicra germline knockout mouse using CRISPR/Cas9. Mice with homozygous loss of Bicra were born at Mendelian ratios but were small, pale and died within 24 hours after birth. Histolog...

Topics

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• B-Lymphocytes
• Cell Movement
• Cytokines
• Mice
• Mice, Knockout
• Phenotype
• Receptors, Cytoplasmic and Nuclear
• X Chromosome Inactivation

Identifiers and source

Literature Corpus work

3f44a534-b3b6-50ad-9d94-337fb369d2cf

DOI

10.1101/2024.10.17.618940