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Article

Ligand effects on cross-linking support a conformational mechanism for serotonin transport.

The Journal of biological chemistry - 4 Dec 2009

Tao Zhen, Zhang Yuan-Wei, Agyiri Alice, Rudnick Gary

Abstract excerpt

Serotonin transporter (SERT) is responsible for the re-uptake of 5-hydroxytryptamine (5-HT) from the synaptic cleft after release from serotonergic neurons. We show here that cysteine residues at positions in transmembranes 1 and 3 of SERT, like the corresponding positions in the gamma-aminobutyric acid transporter, can be cross-linked using copper(II)(1,10-phenanthroline)(3). The presence of a cross-link was...

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Identifiers

PMID: 19837674
DOI: 10.1074/jbc.M109.071977
PMCID: PMC2797150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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