The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.

doi:10.1242/dev.125.7.1207

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.

Development (Cambridge, England) - 1 Apr 1998

Sinclair D A, Milne T A, Hodgson J W, Shellard J, Salinas C A, Kyba M, Randazzo F, Brock H W

Abstract excerpt

The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of homeotic and other loci. Asx is unusual among the Polycomb group because: (1) one Asx allele exhibits both anterior and posterior transformation...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Chromatin
Chromosome Mapping
Chromosomes
Cloning, Molecular
Conserved Sequence
Drosophila
Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Developmental

Immunohistochemistry

Insect Proteins

Molecular Sequence Data

Nuclear Proteins

Phenotype

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 9477319
DOI: 10.1242/dev.125.7.1207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9477319-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.PMID 9477319Read ↗

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.Semantic proximity Read ↗

Genetic analysis of the additional sex combs locus of Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.Semantic proximity Read ↗

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.Semantic proximity Read ↗

Tantalus, a novel ASX-interacting protein with tissue-specific functions.Semantic proximity Read ↗

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.Semantic proximity Read ↗

The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb.Semantic proximity Read ↗

Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster.Semantic proximity Read ↗

The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes.Semantic proximity Read ↗

Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.Semantic proximity Read ↗

Genetic interactions and dosage effects of Polycomb group genes of Drosophila.Semantic proximity Read ↗

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.