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Article

Multiply mutated Gaussia luciferases provide prolonged and intense bioluminescence.

Biochemical and biophysical research communications - 27 Nov 2009

Welsh John P, Patel Kedar G, Manthiram Karthish, Swartz James R

Abstract excerpt

Gaussia luciferase (GLuc) from the copepod Gaussia princeps is both the smallest and brightest known luciferase. GLuc catalyzes the oxidation of coelenterazine to produce an intense blue light but with a very short emission half-life. We report mutated GLucs with much longer luminescence half-lives that retain the same initial intensity as the wild-type enzyme. The GLuc variants were produced using cell-free...

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Identifiers

PMID: 19825431
DOI: 10.1016/j.bbrc.2009.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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