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Elucidating Catalytic Bioluminescence of Mammalian Gaussia Luciferase through Mutant and Ancestral Analysis.

ACS chemical biology - 20 Mar 2026

Borum Raina M, Lanzillotti Michael, Sahasrabuddhe Aniruddha, Hui John O, Cochran Xie Victoria, Ferbas John

Abstract excerpt

A mechanistic basis for luciferase bioluminescence provides a glimpse into its evolutionary role for organism survival, as it provides a blueprint to engineer luciferase enzymes for advanced technological applications. Gaussia Luciferase is among the brightest natural luciferases, but (1) the evolutionary development of its luminescence behavior remains unclear, (2) recent fundamental studies utilized Escherichia...

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PMID: 41688898
DOI: 10.1021/acschembio.5c00925

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