Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.

The Journal of biological chemistry - 4 Dec 2009

Shen Wen, Gao Lu, Balakrishnan Mini, Bambara Robert A

Abstract excerpt

The co-packaged RNA genomes of human immunodeficiency virus-1 recombine at a high rate. Recombination can mix mutations to generate viruses that escape immune response. A cell-culture-based system was designed previously to map recombination events in a 459-bp region spanning the primer binding site through a portion of the gag protein coding region. Strikingly, a strong preferential site for recombination in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cations
Share to Genome, Viral
Share to Guanosine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Reverse Transcriptase

Share to Nucleic Acid Conformation

Share to Viral Proteins

Share to Virus Integration

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19822521
DOI: 10.1074/jbc.M109.055368
PMCID: PMC2797159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.PMID 19822521Read ↗

Identification of a preferred region for recombination and mutation in HIV-1 gag.Semantic proximity Read ↗

The Structure of HIV-1 Genomic RNA in the gp120 Gene Determines a Recombination Hot Spot in VivoSemantic proximity Read ↗

The Nature of Human Immunodeficiency Virus Type 1 Strand TransfersSemantic proximity Read ↗

Specific Guanosines in the HIV-2 Leader RNA are Essential for Efficient Viral Genome Packaging.Semantic proximity Read ↗

In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similaritySemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Recombination: Rate, Fidelity, and Putative Hot SpotsSemantic proximity Read ↗

How to recover from a bad start: adaptation of HIV-1 transcription start site mutants during serial passaging in culture.Semantic proximity Read ↗

Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome.Semantic proximity Read ↗

G-quadruplexes may determine the landscape of recombination in HSV-1Semantic proximity Read ↗

High Rates of Human Immunodeficiency Virus Type 1 Recombination: Near-Random Segregation of Markers One Kilobase Apart in One Round of Viral ReplicationSemantic proximity Read ↗

A short sequence motif in the 5' leader of the HIV-1 genome modulates extended RNA dimer formation and virus replication.Semantic proximity Read ↗

High Rate of Recombination throughout the Human Immunodeficiency Virus Type 1 GenomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.