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Human Immunodeficiency Virus Type 1 Recombination: Rate, Fidelity, and Putative Hot Spots

19 Oct 2002

Abstract excerpt

Previously, we reported that human immunodeficiency virus type 1 (HIV-1) recombines approximately two to three times per genome per replication cycle, an extremely high rate of recombination given the relatively small genome size of HIV-1. However, a recombination hot spot involving sequence of nonretroviral origin was identified in the vector system utilized, raising the possibility that this hot spot skewed the...

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PMID: 12388687
DOI: 10.1128/jvi.76.22.11273-11282.2002

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