Article
A short sequence motif in the 5' leader of the HIV-1 genome modulates extended RNA dimer formation and virus replication.
The Journal of biological chemistry - 19 Dec 2014
van Bel Nikki, Das Atze T, Cornelissen Marion, Abbink Truus E M, Berkhout Ben
Abstract excerpt
The 5' leader of the HIV-1 RNA genome encodes signals that control various steps in the replication cycle, including the dimerization initiation signal (DIS) that triggers RNA dimerization. The DIS folds a hairpin structure with a palindromic sequence in the loop that allows RNA dimerization via intermolecular kissing loop (KL) base pairing. The KL dimer can be stabilized by including the DIS stem nucleotides in...
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