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Article

Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2016

Kharytonchyk Siarhei, Monti Sarah, Smaldino Philip J, Van Verna, Bolden Nicholas C, Brown Joshua D, Russo Emily, Swanson Canessa, Shuey Alex, Telesnitsky Alice, Summers Michael F

Abstract excerpt

The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the U3-R boundary that have been proposed to function as sites for transcription initiation. Here we show that all three sites are used in cells infected with HIV-1 and that viral RNAs containing a single 5' capped guanosine (Cap1G) are specifically selected for packaging in virions, consistent with a recent report [Masuda et...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27834211
DOI: 10.1073/pnas.1616627113
PMCID: PMC5127319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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