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Article

Specific Guanosines in the HIV-2 Leader RNA are Essential for Efficient Viral Genome Packaging.

Journal of molecular biology - 22 Jan 2021

Umunnakwe Chijioke N, Duchon Alice, Nikolaitchik Olga A, Rahman Sheikh Abdul, Liu Yang, Chen Jianbo, Tai Sheldon, Pathak Vinay K, Hu Wei-Shau

Abstract excerpt

HIV-2, a human pathogen that causes acquired immunodeficiency syndrome, is distinct from the more prevalent HIV-1 in several features including its evolutionary history and certain aspects of viral replication. Like other retroviruses, HIV-2 packages two copies of full-length viral RNA during virus assembly and efficient genome encapsidation is mediated by the viral protein Gag. We sought to define cis-acting...

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Share to 5' Untranslated Regions
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Guanosine

Share to Nucleic Acid Conformation

Share to Virus Assembly

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Source

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Identifiers

PMID: 33221337
DOI: 10.1016/j.jmb.2020.11.017
PMCID: PMC9168803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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