Article
A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma.
Genes, chromosomes & cancer - 1 Sept 1990
Rabbitts P, Bergh J, Douglas J, Collins F, Waters J
Abstract excerpt
We have used 14 DNA probes, which detect 19 different restriction enzyme length polymorphisms, to search for heterozygosity on chromosome 3 in five cell lines isolated from patients with small cell lung carcinoma. The cell lines on karyotype analysis did not show the deletion in chromosome 3 characteristic of this disease. Our objective was to determine if allelic loss had occurred by some chromosomal mechanism...
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