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Article

Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.

Diabetes - 1 Sept 2004

Hung Chiao-Chien Connie, Pirie Fraser, Luan Jian'an, Lank Emma, Motala Ayesha, Yeo Giles S H, Keogh Julia M, Wareham Nicholas J, O'Rahilly Stephen, Farooqi I Sadaf

Abstract excerpt

Peptide-YY (PYY) is secreted from endocrine L-cells of the gastrointestinal tract in response to caloric ingestion and may mediate postprandial satiety through the hypothalamic neuropeptide Y2 receptor (Y2R). We examined whether variants in the genes encoding PYY and Y2R might be associated with obesity-related phenotypes in humans. Among 101 subjects with severe early-onset obesity and a history of hyperphagia,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15331560
DOI: 10.2337/diabetes.53.9.2461

Genes

PYY

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.PMID 15331560Read ↗

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Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.Semantic proximity Read ↗

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Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.Semantic proximity Read ↗

A PYY Q62P variant linked to human obesity.Semantic proximity Read ↗

Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents.Semantic proximity Read ↗

Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects.Semantic proximity Read ↗

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Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.Semantic proximity Read ↗

Peptide YY (PYY) Gene Polymorphisms in the 3′-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in VivoSemantic proximity Read ↗

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