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Article

Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.

Diabetes - 1 May 2005

Ma Lijun, Tataranni P Antonio, Hanson Robert L, Infante Aniello M, Kobes Sayuko, Bogardus Clifton, Baier Leslie J

Abstract excerpt

Peptide YY (PYY) and Y2 receptor (Y2R) may be important in the central regulation of body weight and food intake. To determine whether genetic variation in PYY and/or Y2R may contribute to morbid obesity in humans, these genes were sequenced in 83 extremely obese Pima Indians (BMI > or = 50 kg/m2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15855352
DOI: 10.2337/diabetes.54.5.1598
PMCID: PMC1350723

Genes

PYY

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15855352-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.PMID 15855352Read ↗

Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.Semantic proximity Read ↗

Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects.Semantic proximity Read ↗

Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians.Semantic proximity Read ↗

A PYY Q62P variant linked to human obesity.Semantic proximity Read ↗

Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians.Semantic proximity Read ↗

Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents.Semantic proximity Read ↗

Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men.Semantic proximity Read ↗

No association of peptide tyrosine-tyrosine (PYY) gene R72T variant with obesity in the Kampar Health Clinic cohort, Malaysia.Semantic proximity Read ↗

Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.Semantic proximity Read ↗

Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects.Semantic proximity Read ↗

Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men.Semantic proximity Read ↗

Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.Semantic proximity Read ↗

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