Article
Association of HMGB1 polymorphisms with outcome after allogeneic hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Feb 2010
Kornblit Brian, Masmas Tania, Petersen Søren L, Madsen Hans O, Heilmann Carsten, Schejbel Lone, Sengeløv Henrik, Müller Klaus, Garred Peter, Vindeløv Lars
Abstract excerpt
Several studies have demonstrated that genetic variation in cytokine genes can modulate the immune reactions after allogeneic hematopoietic cell transplantation (HCT). High mobility group box 1 protein (HMBG1) is a pleiotropic cytokine that functions as a pro-inflammatory signal, important for the activation of antigen presenting cells (APCs) and propagation of inflammation. HMGB1 is implicated in the...
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