Toll-like receptor polymorphisms in allogeneic hematopoietic cell transplantation.

doi:10.1016/j.bbmt.2014.09.016

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Article

Toll-like receptor polymorphisms in allogeneic hematopoietic cell transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Feb 2015

Kornblit Brian, Enevold Christian, Wang Tao, Spellman Stephen, Haagenson Mike, Lee Stephanie J, Müller Klaus

Abstract excerpt

To assess the impact of the genetic variation in toll-like receptors (TLRs) on outcome after allogeneic myeloablative conditioning hematopoietic cell transplantation (HCT), we investigated 29 single nucleotide polymorphisms across 10 TLRs in 816 patients and donors. Only donor genotype of TLR8 rs3764879, which is located on the X chromosome, was significantly associated with outcome at the Bonferroni-corrected...

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Identifiers

PMID: 25464115
DOI: 10.1016/j.bbmt.2014.09.016
PMCID: PMC4297590

Genes

TLR8

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