Article
Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Leukemia & lymphoma - 1 Feb 2017
Balassa Katalin, Krahling Tunde, Remenyi Peter, Batai Arpad, Bors Andras, Kiss Katalin Piroska, Torbagyi Eva, Gopcsa Laszlo, Lengyel Lilla, Barta Aniko, Varga Gergely, Tordai Attila, Masszi Tamas, Andrikovics Hajnalka
Abstract excerpt
Several genetic polymorphisms have been implicated to affect the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of cytokines in acute graft-versus-host disease (aGvHD) is well established and many of the involved cytokines signal through the Janus kinase (JAK) pathways. In this study, we assessed the association of recipient and donor JAK2 46/1 haplotypes and allo-HSCT outcome...
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