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Article

Prognostic significance of inflammatory cytokine polymorphisms in AML: a study of IFNG, TNFA, and IL1B polymorphisms.

BMC immunology - 2 May 2026

Munkh-Erdene Tsatsralgerel, Saitoh Takayuki, Kitamura Miri, Kojima Asumi, Okawa Takafumi, Oda Tsukasa, Miyauchi Eiji, Sasaki Nobuo, Matsumura Ikuko, Matsumoto Akira, Takei Hisashi, Kobayashi Nobuhiko, Miyazawa Yuri, Ogawa Yoshiyuki, Handa Hiroshi, Gotoh Nanami

Abstract excerpt

BACKGROUND: Inflammatory cytokines influence the pathogenesis and progression of acute myeloid leukaemia (AML), not only by shaping the leukemic microenvironment, but also by supporting leukaemia stem cell survival and resistance to therapy. We, therefore, investigated the associations between the cytokine polymorphisms IFNG+874 A/T, TNFA-857 C/T, and IL1B -31 C/T and AML outcomes, as well as their influence on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Identifiers

PMID: 42070020
DOI: 10.1186/s12865-026-00837-5
PMCID: PMC13361117

Genes

IFNG
IL1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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