Article
Polymorphism in TGFB1 is associated with worse non-relapse mortality and overall survival after stem cell transplantation with unrelated donors.
Haematologica - 1 Mar 2016
Arrieta-Bolaños Esteban, Mayor Neema P, Marsh Steven G E, Madrigal J Alejandro, Apperley Jane F, Kirkland Keiren, Mackinnon Stephen, Marks David I, McQuaker Grant, Perry Julia, Potter Michael N, Russell Nigel H, Thomson Kirsty, Shaw Bronwen E
Abstract excerpt
Transforming growth factor β-1, encoded by the TGFB1 gene, is a cytokine that plays a central role in many physiological and pathogenic processes. We have sequenced TGFB1 regulatory region and assigned allelic genotypes in a large cohort of hematopoietic stem cell transplantation patients and donors. In this study, we analyzed 522 unrelated donor-patient pairs and examined the combined effect of all the common...
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