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Article

Impact of germline predisposition genes to hematologic malignancies on transplant outcomes and donor selection.

Frontiers in immunology - 1 Jan 2026

Li Zhihui, Yang Keyan, Zhang Caiyan, Wang Xianxuan, Wang Lei, Li Jing, Wen Xiaopei, Fei Qian, Zhai Jiahong, Zhou Yan, Ming Zongyang, Song Yanzhi, Zhao Yongqiang, Wu Tong, Zheng Qinlong

Abstract excerpt

Introduction: Germline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: This retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case) evaluated the impact of germline predisposition gene mutations on outcomes. Results: Enrichment of HAVCR2 mutations in B-NHL and UNC13D mutations in MDS was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42582185
DOI: 10.3389/fimmu.2026.1880348
PMCID: PMC13457106

Genes

HAVCR2
UNC13D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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