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Article

A Mutation-Selection Model of Protein Evolution under Persistent Positive Selection.

Molecular biology and evolution - 7 Jan 2022

Tamuri Asif U, Dos Reis Mario

Abstract excerpt

We use first principles of population genetics to model the evolution of proteins under persistent positive selection (PPS). PPS may occur when organisms are subjected to persistent environmental change, during adaptive radiations, or in host-pathogen interactions. Our mutation-selection model indicates protein evolution under PPS is an irreversible Markov process, and thus proteins under PPS show a strongly...

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Identifiers

PMID: 34694387
DOI: 10.1093/molbev/msab309
PMCID: PMC8760937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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