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Article

Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2010

Rodrigue Nicolas, Philippe Hervé, Lartillot Nicolas

Abstract excerpt

Modeling the interplay between mutation and selection at the molecular level is key to evolutionary studies. To this end, codon-based evolutionary models have been proposed as pertinent means of studying long-range evolutionary patterns and are widely used. However, these approaches have not yet consolidated results from amino acid level phylogenetic studies showing that selection acting on proteins displays...

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Identifiers

PMID: 20176949
DOI: 10.1073/pnas.0910915107
PMCID: PMC2842053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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