Article
Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles.
Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2010
Rodrigue Nicolas, Philippe Hervé, Lartillot Nicolas
Abstract excerpt
Modeling the interplay between mutation and selection at the molecular level is key to evolutionary studies. To this end, codon-based evolutionary models have been proposed as pertinent means of studying long-range evolutionary patterns and are widely used. However, these approaches have not yet consolidated results from amino acid level phylogenetic studies showing that selection acting on proteins displays...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Amino Acids
- Codon
- Evolution, Molecular
- Globins
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Selection, Genetic