Models of protein sequence evolution and their applications.

doi:10.1016/s0959-437x(00)00142-8

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Article

Models of protein sequence evolution and their applications.

Current opinion in genetics & development - 1 Dec 2000

Thorne J L

Abstract excerpt

Homologous sequences are correlated due to their common ancestry. Probabilistic models of sequence evolution are employed routinely to properly account for these phylogenetic correlations. These increasingly realistic models provide a basis for studying evolution and for exploiting it to better understand protein structure and function. Notable recent advances have been made in the treatment of insertion and...

Topics

Amino Acid Sequence
Animals
Codon
Evolution, Molecular
Genetic Variation
Models, Genetic
Mutagenesis, Insertional
Point Mutation
Protein Structure, Secondary
Proteins
Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 11088008
DOI: 10.1016/s0959-437x(00)00142-8

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