Article
Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages.
Molecular biology and evolution - 1 Jun 2002
Yang Ziheng, Nielsen Rasmus
Abstract excerpt
The nonsynonymous (amino acid-altering) to synonymous (silent) substitution rate ratio (omega = d(N)/d(S)) provides a measure of natural selection at the protein level, with omega = 1, >1, and <1, indicating neutral evolution, purifying selection, and positive selection, respectively. Previous studies that used this measure to detect positive selection have often taken an approach of pairwise comparison,...
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