Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.

PloS one - 7 Oct 2009

Cain Jason E, Islam Epshita, Haxho Fiona, Chen Lin, Bridgewater Darren, Nieuwenhuis Erica, Hui Chi-Chung, Rosenblum Norman D

Abstract excerpt

Truncating GLI3 mutations in Pallister-Hall Syndrome with renal malformation suggests a requirement for Hedgehog signaling during renal development. HH-dependent signaling increases levels of GLI transcriptional activators and decreases processing of GLI3 to a shorter transcriptional repressor. Previously, we showed that Shh-deficiency interrupts early inductive events during renal development in a manner...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Kidney
Share to Kruppel-Like Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nephrons

Share to Proto-Oncogene Proteins c-ret

Share to Ureter

Share to Wnt Proteins

Share to Zinc Finger Protein Gli3

Source

Open in PubMed Open full text

Identifiers

PMID: 19809516
DOI: 10.1371/journal.pone.0007313
PMCID: PMC2754339

Genes

GLI3
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.PMID 19809516Read ↗

GLI3 repressor controls functional development of the mouse ureter.Semantic proximity Read ↗

Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.Semantic proximity Read ↗

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.Semantic proximity Read ↗

Hedgehog signaling is non-cell autonomously activated in the cystic kidney of <i>Arl13b</i> mutant miceSemantic proximity Read ↗

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.Semantic proximity Read ↗

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.Semantic proximity Read ↗

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.Semantic proximity Read ↗

Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.Semantic proximity Read ↗

Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.Semantic proximity Read ↗

Reversal of elevated <i>Gli3</i> in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesisSemantic proximity Read ↗

A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.Semantic proximity Read ↗

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.