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Article

GLI3 repressor controls functional development of the mouse ureter.

The Journal of clinical investigation - 1 Mar 2011

Cain Jason E, Islam Epshita, Haxho Fiona, Blake Joshua, Rosenblum Norman D

Abstract excerpt

Obstructive and nonobstructive forms of hydronephrosis (increased diameter of the renal pelvis and calyces) and hydroureter (dilatation of the ureter) are the most frequently detected antenatal abnormalities, yet the underlying molecular mechanisms are largely undefined. Hedgehog (Hh) proteins control tissue patterning and cell differentiation by promoting GLI-dependent transcriptional activation and by...

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Source

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Identifiers

PMID: 21339645
DOI: 10.1172/JCI45523
PMCID: PMC3049374

Genes

GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

GLI3 repressor controls functional development of the mouse ureter.PMID 21339645Read ↗

Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.Semantic proximity Read ↗

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.Semantic proximity Read ↗

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.Semantic proximity Read ↗

Hedgehog signaling is non-cell autonomously activated in the cystic kidney of <i>Arl13b</i> mutant miceSemantic proximity Read ↗

Pallister-Hall syndrome phenotype in mice mutant for Gli3.Semantic proximity Read ↗

Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.Semantic proximity Read ↗

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.Semantic proximity Read ↗

The Hedgehog Signal Induced Modulation of Bone Morphogenetic Protein Signaling: An Essential Signaling Relay for Urinary Tract MorphogenesisSemantic proximity Read ↗

Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.Semantic proximity Read ↗

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.Semantic proximity Read ↗

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.Semantic proximity Read ↗

Disruption of a Hedgehog-Foxf1-Rspo2 Signaling Axis Leads to Tracheomalacia and a Loss of Sox9+ Tracheal ChondrocytesSemantic proximity Read ↗

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