Article
Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.
Human molecular genetics - 1 Nov 2011
Li Binghua, Rauhauser Alysha A, Dai Julie, Sakthivel Ramanavelan, Igarashi Peter, Jetten Anton M, Attanasio Massimo
Abstract excerpt
Hedgehog (Hh) is a core signaling pathway implicated in fundamental processes during embryonic kidney development. We previously found that loss-of-function mutations in the transcription factor GLIS2, a putative vertebrate ortholog of Drosophila Ci, cause nephronophthisis type 7 in humans and mice. Kidney tubular cells in Glis2-knockout mice acquire mesenchymal phenotype, but the cellular mechanisms of this...
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