Article
Cell of origin strongly influences genetic selection in a mouse model of T-ALL.
Blood - 27 Oct 2011
Berquam-Vrieze Katherine E, Nannapaneni Kishore, Brett Benjamin T, Holmfeldt Linda, Ma Jing, Zagorodna Oksana, Jenkins Nancy A, Copeland Neal G, Meyerholz David K, Knudson C Michael, Mullighan Charles G, Scheetz Todd E, Dupuy Adam J
Abstract excerpt
Identifying the normal cell from which a tumor originates is crucial to understanding the etiology of that cancer. However, retrospective identification of the cell of origin in cancer is challenging because of the accumulation of genetic and epigenetic changes in tumor cells. The biologic state of the cell of origin likely influences the genetic events that drive transformation. We directly tested this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.