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Article

Novel approach for comparing the abilities of quinolones to restrict the emergence of resistant mutants during quinolone exposure.

Antimicrobial agents and chemotherapy - 1 Jan 2010

Malik Muhammad, Hoatam Gerard, Chavda Kalyan, Kerns Robert J, Drlica Karl

Abstract excerpt

An agar-plate assay was adapted to examine aspects of quinolone structure that restrict the emergence of quinolone-mediated quinolone resistance. When Escherichia coli was applied to agar containing nalidixic acid, the number of quinolone-resistant mutants arising during incubation was decreased by raising the drug concentration and by mutations expected to block the induction of the SOS response (recA, lexA);...

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Source

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Identifiers

PMID: 19805561
DOI: 10.1128/AAC.01035-09
PMCID: PMC2798492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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